AI Daily Digest — 2026-03-26

Key Highlights

• ARC-AGI-3 resets the AI reasoning scoreboard — the ARC Prize Foundation’s new benchmark sees frontier models scoring below 1%, with Google’s Gemini Pro topping out at 0.37%, while humans achieve perfect scores. A stark reminder that pattern-matching scale doesn’t equal genuine reasoning.
• Bryan Johnson documents 5-MeO-DMT as a longevity therapy on the All-In Podcast, reporting dramatic “default mode network reset” comparable to decades of psychological rejuvenation, alongside discussion of mitochondrial transplantation and Fox3-based gene therapy as next-generation anti-aging modalities.

Research

ARC-AGI-3 Resets Frontier AI Scoreboard — Rundown

The ARC Prize Foundation unveiled ARC-AGI-3, an advanced reasoning benchmark where humans achieve perfect scores but leading AI models score below 1%. Google’s Gemini Pro achieved the highest result at just 0.37%, demonstrating that while frontier labs rapidly improved on earlier benchmark versions, this new test presents a significant challenge requiring genuine reasoning capabilities rather than expensive brute-force approaches.

Interviews & Conversations

Bryan Johnson: I Just Took the Most Powerful Dose of DMT in the World — All-In Podcast (38 min)

Bryan Johnson describes his experience with 5-MeO-DMT — reportedly 5-10x more powerful than standard DMT — framed as a longevity experiment rather than recreation. He reports that the compound “annihilated” his default mode network (the brain’s self-referential rumination loop), producing effects he describes as “30-40 years of psychological rejuvenation,” including childlike emotional states and dramatically improved interpersonal communication. Johnson’s team measured the experience with structural/functional MRI, EEG, and Kernel’s optical brain interface, building on earlier psilocybin data that showed metabolic resets and microbiome changes. The conversation shifts to next-generation longevity therapies: mitochondrial transplantation using young donor mitochondria (entering phase two trials), iPSC-derived organoids for personalized drug testing, and Fox3 gene therapy for tissue regeneration. Johnson argues psychedelics may be uniquely powerful for brain rejuvenation where other modalities fall short, and speculates they could help humans adapt psychologically to the pace of AI-driven change.

References

1. ARC-AGI-3 Resets Frontier AI Scoreboard — Rundown, 2026-03-26 [blog]
2. Bryan Johnson: I Just Took the Most Powerful Dose of DMT in the World — All-In Podcast, 2026-03-26 [video]

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